![]() ![]() The proportion of time in target glucose range (5.6–10.0 mmol l −1 primary endpoint) was 52.8 ± 12.5% with closed-loop versus 37.7 ± 20.5% with control mean difference, 15.1 percentage points (95% CI 8.0–22.2 P < 0.001). Thirteen participants received closed-loop first and thirteen received control therapy first. The primary endpoint was time in target glucose range (5.6–10.0 mmol l −1). In an open-label, multinational, two-center, randomized crossover trial, 26 adults with type 2 diabetes requiring dialysis (17 men, 9 women, average age 68 ± 11 years (mean ± s.d.), diabetes duration of 20 ± 10 years) underwent two 20-day periods of unrestricted living, comparing the Cambridge fully closed-loop system using faster insulin aspart (‘closed-loop’) with standard insulin therapy and a masked continuous glucose monitor (‘control’) in random order. We evaluated the safety and efficacy of fully closed-loop insulin therapy compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis.
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